Syntheses of Pyridazine Derivatives. IV. Halogenopyridazine 1-Oxides
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چکیده
منابع مشابه
Benzylpiperazine derivatives. IV. Syntheses and cerebral vasodilating activities of 1-benzyl-4-diphenylmethylpiperazine derivatives.
A considerable body of literature exists on the biological activity of compounds containing the piperazine moiety. In the field of 1-benzyl-4-diphenylmethylpiperazines, antihistaminics,2-4) tranquillizers,5,6) and vasodilators7) have been reported. Some of them, such as buclizine (1), meclizine (2) and medibazine (3), have been used clinically. More recently, 1-diphenylmethyl-4-(4-hydroxybenzyl...
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The structure of anisomycin has been determined by X-ray investigation4 and the absolute configuration was confirmed by chemical correlation.5 Anisomycin has attracted considerable synthetic interest, and several synthetic studies, derivative syntheses as well as total syntheses, have been reported.6 Especially, the synthesis of its analogues has revealed the structure-activity relationship of ...
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ةصلاخلا بكرملل ةدیدج تاقتشم ریضحت ىلا ثحبلا يمری 4,3,1 ةیتلاا تلاعافتلا ءارجا للاخ نم لوزایادایاث : ًلاوأ : ب كرملل فیش ةدعاق ریضحت ) 2 و نیما 5 و تبكرم 4,3,1 لوزا یادایاث ( يلیفو یلكوینلا ضیو عتلا ءارجاو ةدعاقلل يرتسلاا ب كرملا نیو كت ى لا يدؤ یل مویدو صلا دیسكوثیا دو جوب ل ثیلاا تاتیسا ومورب عم ) 3 ( ، يذ لا یازاردیھلا عم ھتلعافم تمت ن 99 % د یازاردیھلا قتشم ریضحتل ) 4 ( فیش دعاوق نم د یدع...
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4-(2-(4-Halophenyl)hydrazinyl)-6-phenylpyridazin-3(2H)-ones 1a,b were prepared and treated with phosphorus oxychloride, phosphorus pentasulphide and ethyl chloroformate to give the corresponding chloropyridazine, pyridazinethione, oxazolopyridazine derivatives 2-4, respectively. Compound 2 reacted with hydrazine hydrate to afford hydrazinylpyridazine 7. The reaction of 4-(2-(4-chlorophenyl)hydr...
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Some derivatives of bactobolin were prepared from bactobolin by dehydration or substitution reactions through tris(dimethylamino)alkoxyphosphonium salt formation. A derivative with low toxicity, 6-deoxybactobolin, showed moderate activity against Gram-positive and Gram-negative bacteria including methicillin-resistant Staphylococcus aureus.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1966
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.14.303